ABC-F Proteins Mediate Antibiotic Resistance through Ribosomal Protection

Members of the ABC-F subfamily of ATP-binding cassette proteins mediate resistance to a broad array of clinically important antibiotic classes that target the ribosome of Gram-positive pathogens. The mechanism by which these proteins act has been a subject of long-standing controversy, with two comp...

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Bibliographic Details
Main Authors: Liam K. R. Sharkey, Thomas A. Edwards, Alex J. O’Neill
Format: Article
Language:English
Published: American Society for Microbiology 2016-03-01
Series:mBio
Online Access:http://mbio.asm.org/cgi/content/full/7/2/e01975-15