Differential requirements of protein geranylgeranylation for the virulence of human pathogenic fungi

Differential requirements of protein geranylgeranylation for the virulence of human pathogenic fungi

Protein prenylation is a crucial post-translational modification largely mediated by two heterodimeric enzyme complexes, farnesyltransferase and geranylgeranyltransferase type-I (GGTase-I), each composed of a shared α-subunit and a unique β-subunit. GGTase-I enzymes are validated drug targets that c...

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Bibliographic Details
Main Authors: Ana Camila Oliveira Souza, Qusai Al Abdallah, Kaci DeJarnette, Adela Martin-Vicente, Ashley V. Nywening, Christian DeJarnette, Emily A. Sansevere, Wenbo Ge, Glen E. Palmer, Jarrod R Fortwendel
Format: Article
Language:English
Published: Taylor & Francis Group 2019-01-01
Series:Virulence
Subjects:
aspergillus fumigatus
candida albicans
prenylation
prenyltransferases
geranylgeranylation
geranylgeranyltransferase-i
protein localization
fungal virulence
Online Access:http://dx.doi.org/10.1080/21505594.2019.1620063

Internet

http://dx.doi.org/10.1080/21505594.2019.1620063

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