Axonal Transport of Mutant Superoxide Dismutase 1 and Focal Axonal Abnormalities in the Proximal Axons of Transgenic Mice

Axonal Transport of Mutant Superoxide Dismutase 1 and Focal Axonal Abnormalities in the Proximal Axons of Transgenic Mice

Superoxide dismutase 1 (SOD1), a ubiquitously expressed enzyme, detoxifies superoxide radicals and participates in copper homeostasis. Mutations in this enzyme have been linked to a subset of autosomal dominant cases of familial amyotrophic lateral sclerosis (FALS), a disorder characterized by selec...

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Bibliographic Details
Main Authors: David R. Borchelt, Philip C. Wong, Mark W. Becher, Carlos A. Pardo, Michael K. Lee, Zuo-Shang Xu, Gopal Thinakaran, Nancy A. Jenkins, Neal G. Copeland, Sangram S. Sisodia, Don W. Cleveland, Donald L. Price, Paul N. Hoffman
Format: Article
Language:English
Published: Elsevier 1998-07-01
Series:Neurobiology of Disease
Subjects:
axonal transport
superoxide dismutase 1
slow componentb
familial amyotrophic lateral sclerosis
mutant.
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996198901784

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