miR-636 inhibits EMT, cell proliferation and cell cycle of ovarian cancer by directly targeting transcription factor Gli2 involved in Hedgehog pathway

miR-636 inhibits EMT, cell proliferation and cell cycle of ovarian cancer by directly targeting transcription factor Gli2 involved in Hedgehog pathway

Abstract Background Hedgehog (Hh) signaling pathway, which is essential for cell proliferation and differentiation, is noted to be aberrantly activated in tumor from increasing studies in recent years. MicroRNAs (miRNAs) as an important non-coding RNA in cells have been proven to possess a regulator...

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Bibliographic Details
Main Authors: Jiong Ma, Chunxia Zhou, Xuejun Chen
Format: Article
Language:English
Published: BMC 2021-01-01
Series:Cancer Cell International
Subjects:
miR-636
Gli2
Ovarian cancer
Proliferation
Migration
Online Access:https://doi.org/10.1186/s12935-020-01725-7

Internet

https://doi.org/10.1186/s12935-020-01725-7

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