Inhibitors of neutrophil recruitment identified using transgenic zebrafish to screen a natural product library

Inhibitors of neutrophil recruitment identified using transgenic zebrafish to screen a natural product library

Cell migration is fundamental to the inflammatory response, but uncontrolled cell migration and excess recruitment of neutrophils and other leukocytes can cause damage to the tissue. Here we describe the use of an in vivo model – the Tg(mpx:GFP)i114 zebrafish line, in which neutrophils are labelled...

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Bibliographic Details
Main Authors: Xingang Wang, Anne L. Robertson, Jingyu Li, Ruth Jinfen Chai, Wang Haishan, Pranvera Sadiku, Nikolay V. Ogryzko, Martin Everett, Kanagasundaram Yoganathan, Hongbo Robert Luo, Stephen A. Renshaw, Philip W. Ingham
Format: Article
Language:English
Published: The Company of Biologists 2014-01-01
Series:Disease Models & Mechanisms
Subjects:
Neutrophil
Recruitment
Migration
Drug screen
Zebrafish
Online Access:http://dmm.biologists.org/content/7/1/163

Internet

http://dmm.biologists.org/content/7/1/163

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