Recombinant antibody against Trypanosoma cruzi from patients with chronic Chagas heart disease recognizes mammalian nervous system.

Recombinant antibody against Trypanosoma cruzi from patients with chronic Chagas heart disease recognizes mammalian nervous system.

Background: To deeply understand the role of antibodies in the context of Trypanosoma cruzi infection, we decided to characterize A2R1, a parasite antibody selected from single-chain variable fragment (scFv) phage display libraries constructed from B cells of chronic Chagas heart disease patients. M...

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Bibliographic Details
Main Authors: Leticia L. Niborski, Mariana Potenza, Renato G.S. Chirivi, Leandro Simonetti, Micaela S. Ossowski, Vanina Grippo, Maria May, Daniela I. Staquicini, Adriana Parodi-Talice, Carlos Robello, Marcelo A. Comini, Guillermo D. Alonso, Jos M.H. Raats, Karina A. Gómez
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:EBioMedicine
Subjects:
Chagas disease
Phage-display
Tubulin
Molecular mimicry
Post-translational modification
Digestive system
Online Access:http://www.sciencedirect.com/science/article/pii/S235239642030582X

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http://www.sciencedirect.com/science/article/pii/S235239642030582X

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