Estimation of cell-type composition including T and B cell subtypes for whole blood methylation microarray data

Estimation of cell-type composition including T and B cell subtypes for whole blood methylation microarray data

DNA methylation levels vary markedly by cell-type makeup of a sample. Understanding these differences and estimating the cell-type makeup of a sample is an important aspect of studying DNA methylation. DNA from leukocytes in whole blood is simple to obtain and pervasive in research. However, leuk...

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Bibliographic Details
Main Authors: Lindsay L Waite, Benjamin eWeaver, Kenneth eDay, Xinrui eLi, Kevin eRoberts, Andrew W Gibson, Jeffrey C Edberg, Robert P Kimberly, Devin M Absher, Hemant K Tiwari
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-02-01
Series:Frontiers in Genetics
Subjects:
DNA Methylation
epigenetics
deconvolution
whole blood
B cell subtypes
T cell subtypes
Online Access:http://journal.frontiersin.org/Journal/10.3389/fgene.2016.00023/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fgene.2016.00023/full

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