Chitosan Oligosaccharides Inhibit/Disaggregate Fibrils and Attenuate Amyloid β-Mediated Neurotoxicity

Chitosan Oligosaccharides Inhibit/Disaggregate Fibrils and Attenuate Amyloid β-Mediated Neurotoxicity

Alzheimer’s disease (AD) is characterized by a large number of amyloid-β (Aβ) deposits in the brain. Therefore, inhibiting Aβ aggregation or destabilizing preformed aggregates could be a promising therapeutic target for halting/slowing the progression of AD. Chitosan oligosaccharides (COS) have prev...

Full description

Bibliographic Details
Main Authors: Xueling Dai, Wanqi Hou, Yaxuan Sun, Zhaolan Gao, Shigong Zhu, Zhaofeng Jiang
Format: Article
Language:English
Published: MDPI AG 2015-05-01
Series:International Journal of Molecular Sciences
Subjects:
Alzheimer’s disease
amyloid-β peptide
chitosan oligosaccharides
aggregation
neurotoxicity
Online Access:http://www.mdpi.com/1422-0067/16/5/10526

Internet

http://www.mdpi.com/1422-0067/16/5/10526

Similar Items