Human Three-Finger Protein Lypd6 Is a Negative Modulator of the Cholinergic System in the Brain

Human Three-Finger Protein Lypd6 Is a Negative Modulator of the Cholinergic System in the Brain

Lypd6 is a GPI-tethered protein from the Ly-6/uPAR family expressed in the brain. Lypd6 enhances the Wnt/β-catenin signaling, although its action on nicotinic acetylcholine receptors (nAChRs) have been also proposed. To investigate a cholinergic activity of Lypd6, we studied a recombinant water-solu...

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Bibliographic Details
Main Authors: Dmitrii Kulbatskii, Zakhar Shenkarev, Maxim Bychkov, Eugene Loktyushov, Mikhail Shulepko, Sergey Koshelev, Igor Povarov, Alexander Popov, Steve Peigneur, Anton Chugunov, Sergey Kozlov, Irina Sharonova, Roman Efremov, Vladimir Skrebitsky, Jan Tytgat, Mikhail Kirpichnikov, Ekaterina Lyukmanova
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
Lypd6
nAChR
cognitive function
synaptic plasticity
Ly6/uPAR
three-finger
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.662227/full

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https://www.frontiersin.org/articles/10.3389/fcell.2021.662227/full

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