USP1-dependent RPS16 protein stability drives growth and metastasis of human hepatocellular carcinoma cells

USP1-dependent RPS16 protein stability drives growth and metastasis of human hepatocellular carcinoma cells

Abstract Background Hepatocellular carcinoma (HCC) remains a medical challenge due to its high proliferation and metastasis. Although deubiquitinating enzymes (DUBs) play a key role in regulating protein degradation, their pathological roles in HCC have not been fully elucidated. Methods By using bi...

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Bibliographic Details
Main Authors: Yuning Liao, Zhenlong Shao, Yuan Liu, Xiaohong Xia, Yuanfei Deng, Cuifu Yu, Wenshuang Sun, Weiyao Kong, Xiaoyue He, Fang Liu, Zhiqiang Guo, Guoxing Chen, Daolin Tang, Huoye Gan, Jinbao Liu, Hongbiao Huang
Format: Article
Language:English
Published: BMC 2021-06-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Hepatocellular carcinoma
USP1
RPS16
Degradation
Online Access:https://doi.org/10.1186/s13046-021-02008-3

Internet

https://doi.org/10.1186/s13046-021-02008-3

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