A-Lipoic Acid Alleviates Folic Acid-Induced Renal Damage Through Inhibition of Ferroptosis

Folic acid (FA)-induced acute kidney injury (AKI) is characterized by the disturbance of redox homeostasis, resulting in massive tubular necrosis and inflammation. Α-lipoic acid (LA), as an antioxidant, has been reported to play an important role in renal protection, but the underlying mechanism rem...

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Bibliographic Details
Main Authors: Xue Li, Yu Zou, Yuan-Yuan Fu, Jia Xing, Kai-Yue Wang, Peng-Zhi Wan, Xiao-Yue Zhai
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Physiology
Subjects:
p53
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2021.680544/full