A Common Cancer Risk-Associated Allele in the hTERT Locus Encodes a Dominant Negative Inhibitor of Telomerase.

A Common Cancer Risk-Associated Allele in the hTERT Locus Encodes a Dominant Negative Inhibitor of Telomerase.

The TERT-CLPTM1L region of chromosome 5p15.33 is a multi-cancer susceptibility locus that encodes the reverse transcriptase subunit, hTERT, of the telomerase enzyme. Numerous cancer-associated single-nucleotide polymorphisms (SNPs), including rs10069690, have been identified within the hTERT gene. T...

Full description

Bibliographic Details
Main Authors: Anagha Killedar, Michael D Stutz, Alexander P Sobinoff, Christopher G Tomlinson, Tracy M Bryan, Jonathan Beesley, Georgia Chenevix-Trench, Roger R Reddel, Hilda A Pickett
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-06-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC4459975?pdf=render

Internet

http://europepmc.org/articles/PMC4459975?pdf=render

Similar Items