Loss of Tsc2 in Purkinje cells is associated with autistic-like behavior in a mouse model of tuberous sclerosis complex

Loss of Tsc2 in Purkinje cells is associated with autistic-like behavior in a mouse model of tuberous sclerosis complex

Tuberous sclerosis complex (TSC) is a dominant tumor suppressor disorder caused by mutations in either TSC1 or TSC2. TSC causes substantial neuropathology, often leading to autism spectrum disorders (ASDs) in up to 60% of patients. The anatomic and neurophysiologic links between these two disorders...

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Bibliographic Details
Main Authors: R. Michelle Reith, James McKenna, Henry Wu, S. Shahrukh Hashmi, Seo-Hee Cho, Pramod K. Dash, Michael J. Gambello
Format: Article
Language:English
Published: Elsevier 2013-03-01
Series:Neurobiology of Disease
Subjects:
Purkinje cell
Tuberous sclerosis
Rapamycin
Mouse
Tsc2
Autism
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996112003427

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http://www.sciencedirect.com/science/article/pii/S0969996112003427

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