Anti-Inflammatory Properties of Chemical Probes in Human Whole Blood: Focus on Prostaglandin E2 Production

Anti-Inflammatory Properties of Chemical Probes in Human Whole Blood: Focus on Prostaglandin E2 Production

We screened 57 chemical probes, high-quality tool compounds, and relevant clinically used drugs to investigate their effect on pro-inflammatory prostaglandin E2 (PGE2) production and interleukin-8 (IL-8) secretion in human whole blood. Freshly drawn blood from healthy volunteers and patients with sy...

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Bibliographic Details
Main Authors: Filip Bergqvist, Yvonne Sundström, Ming-Mei Shang, Iva Gunnarsson, Ingrid E. Lundberg, Michael Sundström, Per-Johan Jakobsson, Louise Berg
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Pharmacology
Subjects:
prostaglandin E2
whole blood assay
interleukin-8
inflammation
drug screen
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00613/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2020.00613/full

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