Are Mouse Models of Asthma Appropriate for Investigating the Pathogenesis of Airway Hyper-Responsiveness?

Whether mouse models of chronic asthma can be used to investigate the relationship between airway inflammation/remodelling and airway hyper-responsiveness (AHR) is a vexed question. It raises issues about the extent to which such models replicate key features of the human disease. Here, we review so...

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Bibliographic Details
Main Authors: Rakesh K. Kumar, Paul S. Foster
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-07-01
Series:Frontiers in Physiology
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphys.2012.00312/full