Unraveling Gene Fusions for Drug Repositioning in High-Risk Neuroblastoma

Unraveling Gene Fusions for Drug Repositioning in High-Risk Neuroblastoma

High-risk neuroblastoma (NB) remains a significant therapeutic challenge facing current pediatric oncology patients. Structural variants such as gene fusions have shown an initial promise in enhancing mechanistic understanding of NB and improving survival rates. In this study, we performed a compreh...

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Bibliographic Details
Main Authors: Zhichao Liu, Xi Chen, Ruth Roberts, Ruili Huang, Mike Mikailov, Weida Tong
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Pharmacology
Subjects:
neuroblastoma
structural variants
gene fusions
next-generation sequencing
drug repositioning
precision medicine 3
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.608778/full

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https://www.frontiersin.org/articles/10.3389/fphar.2021.608778/full

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