Rif1 inhibits replication fork progression and controls DNA copy number in Drosophila

Rif1 inhibits replication fork progression and controls DNA copy number in Drosophila

Control of DNA copy number is essential to maintain genome stability and ensure proper cell and tissue function. In Drosophila polyploid cells, the SNF2-domain-containing SUUR protein inhibits replication fork progression within specific regions of the genome to promote DNA underreplication. While d...

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Bibliographic Details
Main Authors: Alexander Munden, Zhan Rong, Amanda Sun, Rama Gangula, Simon Mallal, Jared T Nordman
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-10-01
Series:eLife
Subjects:
DNA replication
common fragile sites
replication timing
genome stability
under replication
polyploid
Online Access:https://elifesciences.org/articles/39140

Internet

https://elifesciences.org/articles/39140

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