PRMT5 Prevents Cardiomyocyte Hypertrophy via Symmetric Dimethylating HoxA9 and Repressing HoxA9 Expression

PRMT5 Prevents Cardiomyocyte Hypertrophy via Symmetric Dimethylating HoxA9 and Repressing HoxA9 Expression

The present study reveals a link between protein arginine methyltransferase 5 (PRMT5) and Homebox A9 (HoxA9) in the regulation of cardiomyocyte hypertrophy. In cardiomyocyte hypertrophy induced by β-adrenergic receptor agonist isoprenaline (ISO), PRMT5 expression was decreased while HoxA9 was upregu...

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Bibliographic Details
Main Authors: Sidong Cai, Rong Liu, Panxia Wang, Jingyan Li, Tingting Xie, Minghui Wang, Yanjun Cao, Zhuoming Li, Peiqing Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Pharmacology
Subjects:
protein arginine methyltransferase 5
homebox A9
cardiomyocyte hypertrophy
symmetric dimethylation
brain natriuretic peptide
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2020.600627/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2020.600627/full

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