Tissue-specific 5-hydroxymethylcytosine landscape of the human genome

Charting the landscape of 5hmC in human tissues is fundamental to understanding its regulatory functions. Here, we systematically profiled the whole-genome 5hmC landscape at single-base resolution for 19 types of human tissues and found 5hmC shows tissue-specific patterns.

Bibliographic Details
Main Authors: Bo He, Chao Zhang, Xiaoxue Zhang, Yu Fan, Hu Zeng, Jun’e Liu, Haowei Meng, Dongsheng Bai, Jinying Peng, Qian Zhang, Wei Tao, Chengqi Yi
Format: Article
Language:English
Published: Nature Publishing Group 2021-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-24425-w