Tissue-specific 5-hydroxymethylcytosine landscape of the human genome
Charting the landscape of 5hmC in human tissues is fundamental to understanding its regulatory functions. Here, we systematically profiled the whole-genome 5hmC landscape at single-base resolution for 19 types of human tissues and found 5hmC shows tissue-specific patterns.
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2021-07-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-24425-w |
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Article |
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doaj-a881fb687b21471b850c6a144a8cec642021-07-18T11:43:08ZengNature Publishing GroupNature Communications2041-17232021-07-0112111210.1038/s41467-021-24425-wTissue-specific 5-hydroxymethylcytosine landscape of the human genomeBo He0Chao Zhang1Xiaoxue Zhang2Yu Fan3Hu Zeng4Jun’e Liu5Haowei Meng6Dongsheng Bai7Jinying Peng8Qian Zhang9Wei Tao10Chengqi Yi11State Key Laboratory of Protein and Plant Gene Research, School of Life Sciences, Peking UniversityKey Laboratory of Cell Proliferation and Differentiation, School of Life Sciences, Peking UniversityState Key Laboratory of Protein and Plant Gene Research, School of Life Sciences, Peking UniversityDepartment of Urology, Peking University First HospitalState Key Laboratory of Protein and Plant Gene Research, School of Life Sciences, Peking UniversityState Key Laboratory of Protein and Plant Gene Research, School of Life Sciences, Peking UniversityState Key Laboratory of Protein and Plant Gene Research, School of Life Sciences, Peking UniversityState Key Laboratory of Protein and Plant Gene Research, School of Life Sciences, Peking UniversityState Key Laboratory of Protein and Plant Gene Research, School of Life Sciences, Peking UniversityDepartment of Urology, Peking University First HospitalKey Laboratory of Cell Proliferation and Differentiation, School of Life Sciences, Peking UniversityState Key Laboratory of Protein and Plant Gene Research, School of Life Sciences, Peking UniversityCharting the landscape of 5hmC in human tissues is fundamental to understanding its regulatory functions. Here, we systematically profiled the whole-genome 5hmC landscape at single-base resolution for 19 types of human tissues and found 5hmC shows tissue-specific patterns.https://doi.org/10.1038/s41467-021-24425-w |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Bo He Chao Zhang Xiaoxue Zhang Yu Fan Hu Zeng Jun’e Liu Haowei Meng Dongsheng Bai Jinying Peng Qian Zhang Wei Tao Chengqi Yi |
| spellingShingle |
Bo He Chao Zhang Xiaoxue Zhang Yu Fan Hu Zeng Jun’e Liu Haowei Meng Dongsheng Bai Jinying Peng Qian Zhang Wei Tao Chengqi Yi Tissue-specific 5-hydroxymethylcytosine landscape of the human genome Nature Communications |
| author_facet |
Bo He Chao Zhang Xiaoxue Zhang Yu Fan Hu Zeng Jun’e Liu Haowei Meng Dongsheng Bai Jinying Peng Qian Zhang Wei Tao Chengqi Yi |
| author_sort |
Bo He |
| title |
Tissue-specific 5-hydroxymethylcytosine landscape of the human genome |
| title_short |
Tissue-specific 5-hydroxymethylcytosine landscape of the human genome |
| title_full |
Tissue-specific 5-hydroxymethylcytosine landscape of the human genome |
| title_fullStr |
Tissue-specific 5-hydroxymethylcytosine landscape of the human genome |
| title_full_unstemmed |
Tissue-specific 5-hydroxymethylcytosine landscape of the human genome |
| title_sort |
tissue-specific 5-hydroxymethylcytosine landscape of the human genome |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2021-07-01 |
| description |
Charting the landscape of 5hmC in human tissues is fundamental to understanding its regulatory functions. Here, we systematically profiled the whole-genome 5hmC landscape at single-base resolution for 19 types of human tissues and found 5hmC shows tissue-specific patterns. |
| url |
https://doi.org/10.1038/s41467-021-24425-w |
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