Flexible, AAV-equipped Genetic Modules for Inducible Control of Gene Expression in Mammalian Brain

Flexible, AAV-equipped Genetic Modules for Inducible Control of Gene Expression in Mammalian Brain

Controlling gene expression in mammalian brain is of utmost importance to causally link the role of gene function to cell circuit dynamics under normal conditions and disease states. We have developed recombinant adeno-associated viruses equipped with tetracycline-controlled genetic switches for ind...

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Bibliographic Details
Main Authors: Godwin K Dogbevia, Martin Roβmanith, Rolf Sprengel, Mazahir T Hasan
Format: Article
Language:English
Published: Elsevier 2016-01-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
brain
inducible and reversible gene expression
Tet systems
recombinant adeno-associated virus
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253117300379

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http://www.sciencedirect.com/science/article/pii/S2162253117300379

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