A Metagenome-Wide Association Study of Gut Microbiome in Patients With Multiple Sclerosis Revealed Novel Disease Pathology

A Metagenome-Wide Association Study of Gut Microbiome in Patients With Multiple Sclerosis Revealed Novel Disease Pathology

While microbiome plays key roles in the etiology of multiple sclerosis (MS), its mechanism remains elusive. Here, we conducted a comprehensive metagenome-wide association study (MWAS) of the relapsing-remitting MS gut microbiome (ncase = 26, ncontrol = 77) in the Japanese population, by using whole-...

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Bibliographic Details
Main Authors: Toshihiro Kishikawa, Kotaro Ogawa, Daisuke Motooka, Akiko Hosokawa, Makoto Kinoshita, Ken Suzuki, Kenichi Yamamoto, Tatsuo Masuda, Yuki Matsumoto, Takuro Nii, Yuichi Maeda, Shota Nakamura, Hidenori Inohara, Hideki Mochizuki, Tatsusada Okuno, Yukinori Okada
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
metagenome shotgun sequencing
genome-wide association study
dysbiosis
gut microbiome
multiple sclerosis
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2020.585973/full

Internet

https://www.frontiersin.org/articles/10.3389/fcimb.2020.585973/full

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