Toll-Like Receptor 4 Triggering Promotes Cytosolic Routing of DC-SIGN-Targeted Antigens for Presentation on MHC Class I

Toll-Like Receptor 4 Triggering Promotes Cytosolic Routing of DC-SIGN-Targeted Antigens for Presentation on MHC Class I

DC-SIGN is an antigen uptake receptor expressed on dendritic cells (DCs) with specificity for glycans present on a broad variety of pathogens and is capable of directing its cargo to MHC-I and MHC-II pathways for the induction of CD8+ and CD4+ T cell responses, respectively. Therefore, DC-SIGN is a...

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Bibliographic Details
Main Authors: Sophie K. Horrevorts, Sanne Duinkerken, Karien Bloem, Pablo Secades, Hakan Kalay, René J. Musters, Sandra J. van Vliet, Juan J. García-Vallejo, Yvette van Kooyk
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-06-01
Series:Frontiers in Immunology
Subjects:
dendritic cells
DC-SIGN
cross-presentation
imaging flow cytometry
toll-like receptor
MHC-I
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01231/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.01231/full

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