Identification of an archaeal presenilin-like intramembrane protease.

Identification of an archaeal presenilin-like intramembrane protease.

BACKGROUND: The GXGD-type diaspartyl intramembrane protease, presenilin, constitutes the catalytic core of the γ-secretase multi-protein complex responsible for activating critical signaling cascades during development and for the production of β-amyloid peptides (Aβ) implicated in Alzheimer's...

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Bibliographic Details
Main Authors: Celia Torres-Arancivia, Carolyn M Ross, Jose Chavez, Zahra Assur, Georgia Dolios, Filippo Mancia, Iban Ubarretxena-Belandia
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2947513?pdf=render

Internet

http://europepmc.org/articles/PMC2947513?pdf=render

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