Efficient in vivo bone formation by BMP-2 engineered human mesenchymal stem cells encapsulated in a projection stereolithographically fabricated hydrogel scaffold

Efficient in vivo bone formation by BMP-2 engineered human mesenchymal stem cells encapsulated in a projection stereolithographically fabricated hydrogel scaffold

Abstract Background Stem cell-based bone tissue engineering shows promise for bone repair but faces some challenges, such as insufficient osteogenesis and limited architecture flexibility of the cell-delivery scaffold. Methods In this study, we first used lentiviral constructs to transduce ex vivo h...

Full description

Bibliographic Details
Main Authors: Hang Lin, Ying Tang, Thomas P. Lozito, Nicholas Oyster, Bing Wang, Rocky S. Tuan
Format: Article
Language:English
Published: BMC 2019-08-01
Series:Stem Cell Research & Therapy
Subjects:
Osteogenesis
Bone tissue engineering
Bone formation
3D bioprinting
Gene therapy
Ex vivo gene transduction
Online Access:http://link.springer.com/article/10.1186/s13287-019-1350-6

Internet

http://link.springer.com/article/10.1186/s13287-019-1350-6

Similar Items