Population-Based Estimates of the Age-Specific Cumulative Risk of Breast Cancer for Pathogenic Variants in <i>CHEK2</i>: Findings from the Australian Breast Cancer Family Registry

Population-Based Estimates of the Age-Specific Cumulative Risk of Breast Cancer for Pathogenic Variants in <i>CHEK2</i>: Findings from the Australian Breast Cancer Family Registry

Case-control studies of breast cancer have consistently shown that pathogenic variants in <i>CHEK2 </i>are associated with about a 3-fold increased risk of breast cancer. Information about the recurrent protein-truncating variant <i>CHEK2</i> c.1100delC dominates this estimat...

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Bibliographic Details
Main Authors: Tú Nguyen-Dumont, James G. Dowty, Jason A. Steen, Anne-Laure Renault, Fleur Hammet, Maryam Mahmoodi, Derrick Theys, Amanda Rewse, Helen Tsimiklis, Ingrid M. Winship, Graham G. Giles, Roger L. Milne, John L. Hopper, Melissa C. Southey
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Cancers
Subjects:
<i>CHEK2</i>
breast cancer
predisposition
genetic risk factors
age-specific cumulative risk
penetrance
Online Access:https://www.mdpi.com/2072-6694/13/6/1378

Internet

https://www.mdpi.com/2072-6694/13/6/1378

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