Collagen density regulates the activity of tumor-infiltrating T cells

Collagen density regulates the activity of tumor-infiltrating T cells

Abstract Background Tumor progression is accompanied by dramatic remodeling of the surrounding extracellular matrix leading to the formation of a tumor-specific ECM, which is often more collagen-rich and of increased stiffness. The altered ECM of the tumor supports cancer growth and metastasis, but...

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Bibliographic Details
Main Authors: Dorota E. Kuczek, Anne Mette H. Larsen, Marie-Louise Thorseth, Marco Carretta, Adrija Kalvisa, Majken S. Siersbæk, Ana Micaela C. Simões, Anne Roslind, Lars H. Engelholm, Elfriede Noessner, Marco Donia, Inge Marie Svane, Per thor Straten, Lars Grøntved, Daniel H. Madsen
Format: Article
Language:English
Published: BMJ Publishing Group 2019-03-01
Series:Journal for ImmunoTherapy of Cancer
Subjects:
Tumor microenvironment
T cell activity
Extracellular matrix
Immune modulation
3D culture
Online Access:http://link.springer.com/article/10.1186/s40425-019-0556-6

Internet

http://link.springer.com/article/10.1186/s40425-019-0556-6

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