Lipidomic and Transcriptomic Basis of Lysosomal Dysfunction in Progranulin Deficiency

Lipidomic and Transcriptomic Basis of Lysosomal Dysfunction in Progranulin Deficiency

Defective lysosomal function defines many neurodegenerative diseases, such as neuronal ceroid lipofuscinoses (NCL) and Niemann-Pick type C (NPC), and is implicated in Alzheimer’s disease (AD) and frontotemporal lobar degeneration (FTLD-TDP) with progranulin (PGRN) deficiency. Here, we show that PGRN...

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Bibliographic Details
Main Authors: Bret M. Evers, Carlos Rodriguez-Navas, Rachel J. Tesla, Janine Prange-Kiel, Catherine R. Wasser, Kyoung Shin Yoo, Jeffrey McDonald, Basar Cenik, Thomas A. Ravenscroft, Florian Plattner, Rosa Rademakers, Gang Yu, Charles L. White, III, Joachim Herz
Format: Article
Language:English
Published: Elsevier 2017-09-01
Series:Cell Reports
Subjects:
neurodegeneration
Alzheimer’s disease
frontotemporal lobar degeneration
lipids
lipidomics
transcriptomics
lysosome
lysosomal storage disorders
neuronal ceroid lipofuscinoses
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717311816

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http://www.sciencedirect.com/science/article/pii/S2211124717311816

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