PARP1 and PARP2 stabilise replication forks at base excision repair intermediates through Fbh1-dependent Rad51 regulation

PARP1 and PARP2 stabilise replication forks at base excision repair intermediates through Fbh1-dependent Rad51 regulation

PARP1 has a well characterised role in DNA break repair and base excision repair, whereas the role of PARP2 is less well understood. Here, the authors show a requirement for PARP2 in stabilising replication forks that encounter base excision repair intermediates.

Bibliographic Details
Main Authors: George E. Ronson, Ann Liza Piberger, Martin R. Higgs, Anna L. Olsen, Grant S. Stewart, Peter J. McHugh, Eva Petermann, Nicholas D. Lakin
Format: Article
Language:English
Published: Nature Publishing Group 2018-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-03159-2

Internet

https://doi.org/10.1038/s41467-018-03159-2

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