PARP1 and PARP2 stabilise replication forks at base excision repair intermediates through Fbh1-dependent Rad51 regulation

PARP1 and PARP2 stabilise replication forks at base excision repair intermediates through Fbh1-dependent Rad51 regulation

PARP1 has a well characterised role in DNA break repair and base excision repair, whereas the role of PARP2 is less well understood. Here, the authors show a requirement for PARP2 in stabilising replication forks that encounter base excision repair intermediates.

Bibliographic Details
Main Authors: George E. Ronson, Ann Liza Piberger, Martin R. Higgs, Anna L. Olsen, Grant S. Stewart, Peter J. McHugh, Eva Petermann, Nicholas D. Lakin
Format: Article
Language:English
Published: Nature Publishing Group 2018-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-03159-2
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spelling doaj-a8b5718ddf664c57b19e95d580a3e43a2021-05-11T09:38:55ZengNature Publishing GroupNature Communications2041-17232018-02-019111210.1038/s41467-018-03159-2PARP1 and PARP2 stabilise replication forks at base excision repair intermediates through Fbh1-dependent Rad51 regulationGeorge E. Ronson0Ann Liza Piberger1Martin R. Higgs2Anna L. Olsen3Grant S. Stewart4Peter J. McHugh5Eva Petermann6Nicholas D. Lakin7Department of Biochemistry, University of OxfordInstitute of Cancer and Genomic Sciences, University of BirminghamInstitute of Cancer and Genomic Sciences, University of BirminghamDepartment of Oncology, Weatherall Institute of Molecular Medicine, University of OxfordInstitute of Cancer and Genomic Sciences, University of BirminghamDepartment of Oncology, Weatherall Institute of Molecular Medicine, University of OxfordInstitute of Cancer and Genomic Sciences, University of BirminghamDepartment of Biochemistry, University of OxfordPARP1 has a well characterised role in DNA break repair and base excision repair, whereas the role of PARP2 is less well understood. Here, the authors show a requirement for PARP2 in stabilising replication forks that encounter base excision repair intermediates.https://doi.org/10.1038/s41467-018-03159-2
collection DOAJ
language English
format Article
sources DOAJ
author George E. Ronson
Ann Liza Piberger
Martin R. Higgs
Anna L. Olsen
Grant S. Stewart
Peter J. McHugh
Eva Petermann
Nicholas D. Lakin
spellingShingle George E. Ronson
Ann Liza Piberger
Martin R. Higgs
Anna L. Olsen
Grant S. Stewart
Peter J. McHugh
Eva Petermann
Nicholas D. Lakin
PARP1 and PARP2 stabilise replication forks at base excision repair intermediates through Fbh1-dependent Rad51 regulation
Nature Communications
author_facet George E. Ronson
Ann Liza Piberger
Martin R. Higgs
Anna L. Olsen
Grant S. Stewart
Peter J. McHugh
Eva Petermann
Nicholas D. Lakin
author_sort George E. Ronson
title PARP1 and PARP2 stabilise replication forks at base excision repair intermediates through Fbh1-dependent Rad51 regulation
title_short PARP1 and PARP2 stabilise replication forks at base excision repair intermediates through Fbh1-dependent Rad51 regulation
title_full PARP1 and PARP2 stabilise replication forks at base excision repair intermediates through Fbh1-dependent Rad51 regulation
title_fullStr PARP1 and PARP2 stabilise replication forks at base excision repair intermediates through Fbh1-dependent Rad51 regulation
title_full_unstemmed PARP1 and PARP2 stabilise replication forks at base excision repair intermediates through Fbh1-dependent Rad51 regulation
title_sort parp1 and parp2 stabilise replication forks at base excision repair intermediates through fbh1-dependent rad51 regulation
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2018-02-01
description PARP1 has a well characterised role in DNA break repair and base excision repair, whereas the role of PARP2 is less well understood. Here, the authors show a requirement for PARP2 in stabilising replication forks that encounter base excision repair intermediates.
url https://doi.org/10.1038/s41467-018-03159-2
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