PARP1 and PARP2 stabilise replication forks at base excision repair intermediates through Fbh1-dependent Rad51 regulation
PARP1 has a well characterised role in DNA break repair and base excision repair, whereas the role of PARP2 is less well understood. Here, the authors show a requirement for PARP2 in stabilising replication forks that encounter base excision repair intermediates.
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2018-02-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-018-03159-2 |
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doaj-a8b5718ddf664c57b19e95d580a3e43a2021-05-11T09:38:55ZengNature Publishing GroupNature Communications2041-17232018-02-019111210.1038/s41467-018-03159-2PARP1 and PARP2 stabilise replication forks at base excision repair intermediates through Fbh1-dependent Rad51 regulationGeorge E. Ronson0Ann Liza Piberger1Martin R. Higgs2Anna L. Olsen3Grant S. Stewart4Peter J. McHugh5Eva Petermann6Nicholas D. Lakin7Department of Biochemistry, University of OxfordInstitute of Cancer and Genomic Sciences, University of BirminghamInstitute of Cancer and Genomic Sciences, University of BirminghamDepartment of Oncology, Weatherall Institute of Molecular Medicine, University of OxfordInstitute of Cancer and Genomic Sciences, University of BirminghamDepartment of Oncology, Weatherall Institute of Molecular Medicine, University of OxfordInstitute of Cancer and Genomic Sciences, University of BirminghamDepartment of Biochemistry, University of OxfordPARP1 has a well characterised role in DNA break repair and base excision repair, whereas the role of PARP2 is less well understood. Here, the authors show a requirement for PARP2 in stabilising replication forks that encounter base excision repair intermediates.https://doi.org/10.1038/s41467-018-03159-2 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
George E. Ronson Ann Liza Piberger Martin R. Higgs Anna L. Olsen Grant S. Stewart Peter J. McHugh Eva Petermann Nicholas D. Lakin |
spellingShingle |
George E. Ronson Ann Liza Piberger Martin R. Higgs Anna L. Olsen Grant S. Stewart Peter J. McHugh Eva Petermann Nicholas D. Lakin PARP1 and PARP2 stabilise replication forks at base excision repair intermediates through Fbh1-dependent Rad51 regulation Nature Communications |
author_facet |
George E. Ronson Ann Liza Piberger Martin R. Higgs Anna L. Olsen Grant S. Stewart Peter J. McHugh Eva Petermann Nicholas D. Lakin |
author_sort |
George E. Ronson |
title |
PARP1 and PARP2 stabilise replication forks at base excision repair intermediates through Fbh1-dependent Rad51 regulation |
title_short |
PARP1 and PARP2 stabilise replication forks at base excision repair intermediates through Fbh1-dependent Rad51 regulation |
title_full |
PARP1 and PARP2 stabilise replication forks at base excision repair intermediates through Fbh1-dependent Rad51 regulation |
title_fullStr |
PARP1 and PARP2 stabilise replication forks at base excision repair intermediates through Fbh1-dependent Rad51 regulation |
title_full_unstemmed |
PARP1 and PARP2 stabilise replication forks at base excision repair intermediates through Fbh1-dependent Rad51 regulation |
title_sort |
parp1 and parp2 stabilise replication forks at base excision repair intermediates through fbh1-dependent rad51 regulation |
publisher |
Nature Publishing Group |
series |
Nature Communications |
issn |
2041-1723 |
publishDate |
2018-02-01 |
description |
PARP1 has a well characterised role in DNA break repair and base excision repair, whereas the role of PARP2 is less well understood. Here, the authors show a requirement for PARP2 in stabilising replication forks that encounter base excision repair intermediates. |
url |
https://doi.org/10.1038/s41467-018-03159-2 |
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