Mitogen-activated protein kinase-activated protein kinase 2 deficiency reduces insulin sensitivity in high-fat diet-fed mice.

Mitogen-activated protein kinase-activated protein kinase 2 deficiency reduces insulin sensitivity in high-fat diet-fed mice.

Adipose tissue inflammation is considered an important contributor to insulin resistance. Mitogen-activated protein kinase-activated protein kinase 2 (MK2) is a major downstream target of p38 MAPK and enhances inflammatory processes. In line with the role of MK2 as contributor to inflammation, MK2-/...

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Bibliographic Details
Main Authors: Jan Freark de Boer, Arne Dikkers, Angelika Jurdzinski, Johann von Felden, Matthias Gaestel, Udo Bavendiek, Uwe J F Tietge
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4169416?pdf=render

Internet

http://europepmc.org/articles/PMC4169416?pdf=render

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