Targeting miR-27a/VE-cadherin interactions rescues cerebral cavernous malformations in mice.

Targeting miR-27a/VE-cadherin interactions rescues cerebral cavernous malformations in mice.

Cerebral cavernous malformations (CCMs) are vascular lesions predominantly developing in the central nervous system (CNS), with no effective treatments other than surgery. Loss-of-function mutation in CCM1/krev interaction trapped 1 (KRIT1), CCM2, or CCM3/programmed cell death 10 (PDCD10) causes les...

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Bibliographic Details
Main Authors: Jia Li, Yang Zhao, Jaesung Choi, Ka Ka Ting, Paul Coleman, Jinbiao Chen, Victoria C Cogger, Li Wan, Zhongsong Shi, Thorleif Moller, Xiangjian Zheng, Mathew A Vadas, Jennifer R Gamble
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-06-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.3000734

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https://doi.org/10.1371/journal.pbio.3000734

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