A Crucial Role for the Protein Quality Control System in Motor Neuron Diseases

A Crucial Role for the Protein Quality Control System in Motor Neuron Diseases

Motor neuron diseases (MNDs) are fatal diseases characterized by loss of motor neurons in the brain cortex, in the bulbar region, and/or in the anterior horns of the spinal cord. While generally sporadic, inherited forms linked to mutant genes encoding altered RNA/protein products have also been des...

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Bibliographic Details
Main Authors: Riccardo Cristofani, Valeria Crippa, Maria Elena Cicardi, Barbara Tedesco, Veronica Ferrari, Marta Chierichetti, Elena Casarotto, Margherita Piccolella, Elio Messi, Mariarita Galbiati, Paola Rusmini, Angelo Poletti
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Aging Neuroscience
Subjects:
motor neuron
protein quality control
CASA complex
HSPB8
BAG3
BAG1
Online Access:https://www.frontiersin.org/article/10.3389/fnagi.2020.00191/full

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https://www.frontiersin.org/article/10.3389/fnagi.2020.00191/full

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