Impact of the Enhanced Permeability and Retention (EPR) Effect and Cathepsins Levels on the Activity of Polymer-Drug Conjugates

Impact of the Enhanced Permeability and Retention (EPR) Effect and Cathepsins Levels on the Activity of Polymer-Drug Conjugates

Polymer-drug conjugates have demonstrated clinical potential in the context of anticancer therapy. However, such promising results have, to date, failed to translate into a marketed product. Polymer-drug conjugates rely on two factors for activity: (i) the presence of a defective vasculature, for pa...

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Bibliographic Details
Main Authors: Amit K. Rajora, Divyashree Ravishankar, Helen M. I. Osborn, Francesca Greco
Format: Article
Language:English
Published: MDPI AG 2014-08-01
Series:Polymers
Subjects:
polymer-drug conjugate
enhanced permeability and retention effect
cathepsin
tumour microenvironment
Online Access:http://www.mdpi.com/2073-4360/6/8/2186

Internet

http://www.mdpi.com/2073-4360/6/8/2186

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