The targetable nanoparticle BAF312@cRGD-CaP-NP represses tumor growth and angiogenesis by downregulating the S1PR1/P-STAT3/VEGFA axis in triple-negative breast cancer

The targetable nanoparticle BAF312@cRGD-CaP-NP represses tumor growth and angiogenesis by downregulating the S1PR1/P-STAT3/VEGFA axis in triple-negative breast cancer

Abstract Background Overexpressed vascular endothelial growth factor A (VEGFA) and phosphorylated signal transducer and activator of transcription 3 (P-STAT3) cause unrestricted tumor growth and angiogenesis of breast cancer (BRCA), especially triple-negative breast cancer (TNBC). Hence, novel treat...

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Bibliographic Details
Main Authors: Ke Gong, Juyang Jiao, Chaoqun Xu, Yang Dong, Dongxiao Li, Di He, De Zhao, Jian Yu, Ying Sun, Wei Zhang, Min Bai, Yourong Duan
Format: Article
Language:English
Published: BMC 2021-05-01
Series:Journal of Nanobiotechnology
Subjects:
Targeted nanoparticle
S1PR1
P-STAT3
VEGFA
BAF312
Triple-negative breast cancer
Online Access:https://doi.org/10.1186/s12951-021-00904-6

Internet

https://doi.org/10.1186/s12951-021-00904-6

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