High circulating SDF-1and MCP-1 levels and genetic variations in CXCL12, CCL2 and CCR5: Prognostic signature of immune recovery status in treated HIV-positive patients

High circulating SDF-1and MCP-1 levels and genetic variations in CXCL12, CCL2 and CCR5: Prognostic signature of immune recovery status in treated HIV-positive patients

ABSTRACT: Background: The underlying mechanisms of incomplete immune reconstitution in treated HIV-positive patients are very complex and may be multifactorial, but perturbation of chemokine secretion could play a key role in CD4+ T-cell turnover. Methods: We evaluated the circulating baseline and...

Full description

Bibliographic Details
Main Authors: Elena Yeregui, Consuelo Viladés, Pere Domingo, Andra Ceausu, Yolanda María Pacheco, Sergi Veloso, Alexy Inciarte, Judit Vidal-González, Maria Peraire, Carles Perpiñán, Vicenç Falcó, Jenifer Masip, Verónica Alba, Montserrat Vargas, Anna Martí, Laia Reverté, Josep Mallolas, Francesc Vidal, Joaquim Peraire, Anna Rull
Format: Article
Language:English
Published: Elsevier 2020-12-01
Series:EBioMedicine
Subjects:
Chemokines
Chemokine receptors
HIV
Poor immune recovery
Polymorphisms variants
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396420304539

Internet

http://www.sciencedirect.com/science/article/pii/S2352396420304539

Similar Items