Design and Synthesis of Novel Imidazole Derivatives Possessing Triazole Pharmacophore with Potent Anticancer Activity, and In Silico ADMET with GSK-3β Molecular Docking Investigations

Design and Synthesis of Novel Imidazole Derivatives Possessing Triazole Pharmacophore with Potent Anticancer Activity, and In Silico ADMET with GSK-3β Molecular Docking Investigations

A library of novel imidazole-1,2,3-triazole hybrids were designed and synthesized based on the hybrid pharmacophore approach. Therefore, copper(I)catalyzed click reaction of thiopropargylated-imidazole 2 with several organoazides yielded two sets of imidazole-1,2,3-triazole hybrids carrying differen...

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Bibliographic Details
Main Authors: Fawzia Al-blewi, Salma Akram Shaikh, Arshi Naqvi, Faizah Aljohani, Mohamed Reda Aouad, Saleh Ihmaid, Nadjet Rezki
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:International Journal of Molecular Sciences
Subjects:
1,2,3-triazole
imidazole
click synthesis
anticancer activity
docking study
Online Access:https://www.mdpi.com/1422-0067/22/3/1162

Internet

https://www.mdpi.com/1422-0067/22/3/1162

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