Ubiquitination and sumoylation of the HTLV-2 Tax-2B protein regulate its NF-κB activity: a comparative study with the HTLV-1 Tax-1 protein

Ubiquitination and sumoylation of the HTLV-2 Tax-2B protein regulate its NF-κB activity: a comparative study with the HTLV-1 Tax-1 protein

<p>Abstract</p> <p>Background</p> <p>Retroviruses HTLV-1 and HTLV-2 have homologous genomic structures but differ significantly in pathogenicity. HTLV-1 is associated with Adult T cell Leukemia (ATL), whereas infection by HTLV-2 has no association with neoplasia. Transf...

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Bibliographic Details
Main Authors: Turci Marco, Lodewick Julie, Di Gennaro Gianfranco, Rinaldi Anne, Marin Oriano, Diani Erica, Sampaio Carla, Bex Françoise, Bertazzoni Umberto, Romanelli Maria
Format: Article
Language:English
Published: BMC 2012-12-01
Series:Retrovirology
Subjects:
HTLV-1
HTLV-2
Retrovirus
Tax
Oncoprotein
Leukemia
Post-translational modification
Ubiquitination
Sumoylation
NF-κB pathway
Online Access:http://www.retrovirology.com/content/9/1/102

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http://www.retrovirology.com/content/9/1/102

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