Nicotine Induces the Production of IL-1ß and IL-8 via the a7 nAChR/NF-κB Pathway in Human Periodontal Ligament Cells: an in Vitro Study

Nicotine Induces the Production of IL-1ß and IL-8 via the a7 nAChR/NF-κB Pathway in Human Periodontal Ligament Cells: an in Vitro Study

Background/Aims: Tobacco smoking is a major risk factor for the occurrence and progression of periodontitis. We previously demonstrated that nicotine could induce the expression of a7 nicotinic acetylcholine receptors (a7 nAChR) in human and rat periodontal tissues. To further examine the signal pat...

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Bibliographic Details
Main Authors: Lizheng Wu, Yongchuan Zhou, Zhifei Zhou, Yingfeng Liu, Yudi Bai, Xianghui Xing, Xiaojing Wang
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2014-07-01
Series:Cellular Physiology and Biochemistry
Subjects:
Periodontal ligament cells
Periodontitis
Nicotine
α7 nicotinic acetylcholine receptor
NF-kappa B
Online Access:http://www.karger.com/Article/FullText/363011

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http://www.karger.com/Article/FullText/363011

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