Durable targeting of B-lymphocytes in living mice

Abstract Transfer to and enduring expression of genes in B cells has proved a vexing challenge. We report here a novel method for the specific and durable targeting of B lymphocytes in living mice. The method involves generation of lentiviruses pseudotyped with an anti-CD19 antibody. CD19 targeting...

Full description

Bibliographic Details
Main Authors: M. Cascalho, D. Huynh, A. R. Lefferts, L. Stein, T. Lanigan, J. Decker, L. D. Shea, J. L. Platt
Format: Article
Language:English
Published: Nature Publishing Group 2018-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-018-29452-0