The EspF N-Terminal of Enterohemorrhagic Escherichia coli O157:H7 EDL933w Imparts Stronger Toxicity Effects on HT-29 Cells than the C-Terminal

The EspF N-Terminal of Enterohemorrhagic Escherichia coli O157:H7 EDL933w Imparts Stronger Toxicity Effects on HT-29 Cells than the C-Terminal

Enterohemorrhagic Escherichia coli (EHEC) O157:H7 EspF is an important multifunctional protein that destroys the tight junctions of intestinal epithelial cells and promotes host cell apoptosis. However, its molecular mechanism remains elusive. We knocked out the espF sequence (747 bp, ΔespF), N-term...

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Bibliographic Details
Main Authors: Xiangyu Wang, Yanli Du, Ying Hua, Muqing Fu, Cong Niu, Bao Zhang, Wei Zhao, Qiwei Zhang, Chengsong Wan
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-09-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Enterohemorrhagic Escherichia coli O157:H7
espF
Gene knockout
EspF N-terminal
apoptosis
inflammation
Online Access:http://journal.frontiersin.org/article/10.3389/fcimb.2017.00410/full

Internet

http://journal.frontiersin.org/article/10.3389/fcimb.2017.00410/full

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