PP2A/B55 and Fcp1 regulate Greatwall and Ensa dephosphorylation during mitotic exit.

PP2A/B55 and Fcp1 regulate Greatwall and Ensa dephosphorylation during mitotic exit.

Entry into mitosis is triggered by activation of Cdk1 and inactivation of its counteracting phosphatase PP2A/B55. Greatwall kinase inactivates PP2A/B55 via its substrates Ensa and ARPP19. Both Greatwall and Ensa/ARPP19 are regulated by phosphorylation, but the dynamic regulation of Greatwall activit...

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Bibliographic Details
Main Authors: Nadia Hégarat, Clare Vesely, P K Vinod, Cory Ocasio, Nisha Peter, Julian Gannon, Antony W Oliver, Béla Novák, Helfrid Hochegger
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC3879168?pdf=render

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