Amphidinol 3 preferentially binds to cholesterol in disordered domains and disrupts membrane phase separation

Amphidinol 3 preferentially binds to cholesterol in disordered domains and disrupts membrane phase separation

Amphidinol 3 (AM3), a polyhydroxy-polyene metabolite from the dinoflagellate Amphidinium klebsii, possesses potent antifungal activity. AM3 is known to interact directly with membrane sterols and permeabilize membranes by forming pores. Because AM3 binds to sterols such as cholesterol and ergosterol...

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Bibliographic Details
Main Authors: Manami Hieda, Akira Sorada, Masanao Kinoshita, Nobuaki Matsumori
Format: Article
Language:English
Published: Elsevier 2021-07-01
Series:Biochemistry and Biophysics Reports
Subjects:
Amphidinol 3
Cholesterol
Membrane
Fluorescence microscope
Lipid rafts
Phase separation
Online Access:http://www.sciencedirect.com/science/article/pii/S2405580821000352

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http://www.sciencedirect.com/science/article/pii/S2405580821000352

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