Design and Synthesis of Novel Breast Cancer Therapeutic Drug Candidates Based upon the Hydrophobic Feedback Approach of Antiestrogens
Based upon hydrophobic feedback approaches, we designed and synthesized novel sulfur-containing ERα modulators (<b>4</b> and <b>5</b>) as breast cancer therapeutic drug candidates. The tetrahydrothiepine derivative <b>5a</b> showed the highest binding aff...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2019-11-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/24/21/3966 |