Design, Synthesis, and Evaluation of Dihydropyranopyrazole Derivatives as Novel PDE2 Inhibitors for the Treatment of Alzheimer’s Disease

Design, Synthesis, and Evaluation of Dihydropyranopyrazole Derivatives as Novel PDE2 Inhibitors for the Treatment of Alzheimer’s Disease

Phosphodiesterase 2 (PDE2) has been regarded as a novel target for the treatment of Alzheimer’s disease (AD). In this study, we obtained (<b><i>R</i></b>)-<b>LZ77</b> as a hit compound with moderate PDE2 inhibitory activity (IC<sub>50</sub> = 261.3 nM)...

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Bibliographic Details
Main Authors: Yan Zhou, Jinjian Li, Han Yuan, Rui Su, Yue Huang, Yiyou Huang, Zhe Li, Yinuo Wu, Haibin Luo, Chen Zhang, Ling Huang
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Molecules
Subjects:
dihydropyranopyrazole derivatives
PDE2 inhibitors
Alzheimer’s disease
Online Access:https://www.mdpi.com/1420-3049/26/10/3034

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https://www.mdpi.com/1420-3049/26/10/3034

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