Insights into P-Glycoprotein Inhibitors: New Inducers of Immunogenic Cell Death

Insights into P-Glycoprotein Inhibitors: New Inducers of Immunogenic Cell Death

Doxorubicin is a strong inducer of immunogenic cell death (ICD), but it is ineffective in P-glycoprotein (Pgp)-expressing cells. Indeed, Pgp effluxes doxorubicin and impairs the immunesensitizing functions of calreticulin (CRT), an “eat-me” signal mediating ICD. It is unknown if classical Pgp inhibi...

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Bibliographic Details
Main Authors: Joanna Kopecka, Martina Godel, Silvia Dei, Roberta Giampietro, Dimas Carolina Belisario, Muhlis Akman, Marialessandra Contino, Elisabetta Teodori, Chiara Riganti
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Cells
Subjects:
doxorubicin resistance
P-glycoprotein
calreticulin
triple negative breast cancer
Online Access:https://www.mdpi.com/2073-4409/9/4/1033

Internet

https://www.mdpi.com/2073-4409/9/4/1033

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