Downregulation of the DNA Repair Gene DDB2 by Arecoline Is through p53’s DNA-Binding Domain and Is Correlated with Poor Outcome of Head and Neck Cancer Patients with Betel Quid Consumption

Downregulation of the DNA Repair Gene DDB2 by Arecoline Is through p53’s DNA-Binding Domain and Is Correlated with Poor Outcome of Head and Neck Cancer Patients with Betel Quid Consumption

Arecoline is the principal alkaloid in the areca nut, a component of betel quids (BQs), which are carcinogenic to humans. Epidemiological studies indicate that BQ-chewing contributes to the occurrence of head and neck cancer (HNC). Previously, we have reported that arecoline (0.3 mM) is able to inhi...

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Bibliographic Details
Main Authors: Yu-Chu Wang, Jau-Ling Huang, Ka-Wo Lee, Hsing-Han Lu, Yuan-Jen Lin, Long-Fong Chen, Chung-Sheng Wang, Yun-Chiao Cheng, Zih-Ting Zeng, Pei-Yi Chu, Chang-Shen Lin
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Cancers
Subjects:
arecoline
betel quid
DDB2
DNA repair
head and neck cancer
p53
Online Access:https://www.mdpi.com/2072-6694/12/8/2053

Internet

https://www.mdpi.com/2072-6694/12/8/2053

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