Replacement of TCR Dβ With Immunoglobulin DH DSP2.3 Imposes a Tyrosine-Enriched TCR Repertoire and Adversely Affects T Cell Development

Replacement of TCR Dβ With Immunoglobulin DH DSP2.3 Imposes a Tyrosine-Enriched TCR Repertoire and Adversely Affects T Cell Development

Enrichment for tyrosine in immunoglobulin CDR-H3 is due in large part to natural selection of germline immunoglobulin DH sequence. We have previously shown that when DH sequence is modified to reduce the contribution of tyrosine codons, epitope recognition is altered and B cell development, antibody...

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Bibliographic Details
Main Authors: Michael Levinson, Mohamed Khass, Peter D. Burrows, Harry W. Schroeder
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Immunology
Subjects:
germline selection
CDR-B3
TCRB diversity
Db1
immunoglobulin DSP2.3
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.573413/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.573413/full

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