Anthraquinones as Inhibitors of SOS RAS-GEF Activity

Recent breakthroughs have reignited interest in RAS GEFs as direct therapeutic targets. To search for new inhibitors of SOS GEF activity, a repository of known/approved compounds (NIH-NACTS) and a library of new marine compounds (Biomar Microbial Technologies) were screened by means of in vitro RAS-...

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Bibliographic Details
Main Authors: Alberto Fernández-Medarde, Rocío Fuentes-Mateos, Rósula García-Navas, Andrea Olarte-San Juan, José María Sánchez-López, Antonio Fernández-Medarde, Eugenio Santos
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Biomolecules
Subjects:
SOS
Online Access:https://www.mdpi.com/2218-273X/11/8/1128