Zika virus antagonizes interferon response in patients and disrupts RIG-I–MAVS interaction through its CARD-TM domains

Zika virus antagonizes interferon response in patients and disrupts RIG-I–MAVS interaction through its CARD-TM domains

Abstract Background The emerging threat to global health associated with the Zika virus (ZIKV) epidemics and its link to severe complications highlights a growing need to better understand the pathogenic mechanisms of ZIKV. Accumulating evidence for a critical role of type I interferon (IFN-I) in pr...

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Bibliographic Details
Main Authors: Yiwen Hu, Xinhuai Dong, Zhenjian He, Yun Wu, Shihao Zhang, Jiajie Lin, Yi Yang, Jiahui Chen, Shu An, Yingxian Yin, Zhiyong Shen, Gucheng Zeng, Han Tian, Junchao Cai, Hongyu Guan, Jueheng Wu, Mengfeng Li, Xun Zhu
Format: Article
Language:English
Published: BMC 2019-06-01
Series:Cell & Bioscience
Subjects:
Zika virus
Nonstructural protein 4A
Interferon
RIG-I
MAVS
Online Access:http://link.springer.com/article/10.1186/s13578-019-0308-9

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http://link.springer.com/article/10.1186/s13578-019-0308-9

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